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John A Josey Selected Research

PT2385

11/2018Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385).
1/2018Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma.
1/2016A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.

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John A Josey Research Topics

Disease

4Renal Cell Carcinoma (Grawitz Tumor)
01/2019 - 11/2016
4Hypoxia (Hypoxemia)
01/2019 - 01/2016
3Neoplasms (Cancer)
11/2018 - 09/2012
1Edema (Dropsy)
01/2018
1Anemia
01/2018
1Fatigue
01/2018
1Carcinogenesis
11/2016
1Kidney Neoplasms (Kidney Cancer)
11/2016
1Pain (Aches)
09/2012
1Osteoarthritis
04/2011
1Chronic Hepatitis C
12/2008
1Body Weight (Weight, Body)
12/2008

Drug/Important Bio-Agent (IBA)

4Transcription Factors (Transcription Factor)IBA
11/2018 - 01/2016
3PT2385IBA
11/2018 - 01/2016
2Proteins (Proteins, Gene)FDA Link
11/2018 - 11/2016
2PT2399IBA
11/2016 - 11/2016
1belzutifanIBA
01/2019
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
11/2018
1Biomarkers (Surrogate Marker)IBA
11/2016
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2016
1Plasminogen Activator Inhibitor 1IBA
01/2016
1Cyclin D1IBA
01/2016
1Phosphotransferases (Kinase)IBA
09/2012
1tyrosine receptor (receptor, tyrosine)IBA
09/2012
1ADAMTS5 ProteinIBA
04/2011
1EnzymesIBA
04/2011
1ADAMTS4 ProteinIBA
04/2011
1danoprevirIBA
12/2008
1RNA (Ribonucleic Acid)IBA
12/2008